The effect of colchicine on mortality outcome and duration of hospital stay in patients with COVID-19: A meta-analysis of randomized trials.

ABSTRACT:

Background

Overactivation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome can lead to severe illness in patients with coronavirus disease-2019 (COVID-19). The NLRP3 inhibitor, colchicine, therefore, appears to be promising for the treatment of COVID-19.

Aims

We aimed to perform a meta-analysis of randomized trials investigating the effect of colchicine in patients with COVID-19.

Materials & methods

We systematically searched electronic databases and clinical trial registries (up to October 17, 2021) for eligible studies. The outcomes of interest were all-cause mortality and duration of hospital stay. Meta-analysis with the random-effects model was used to estimate the pooled odds ratio (OR) of mortality and 95% confidence interval (CI). The pooled sta

SUBMITTER: Kow CS 

PROVIDER: S-EPMC8767506 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature