Characterization of Prelaminar Wedge-Shaped Defects in Primary Open-Angle Glaucoma.

ABSTRACT:

Purpose

To determine the clinical relevance of prelaminar wedge defects (PLWDs) detected by swept-source optical coherence tomography (SS-OCT) in primary open-angle glaucoma (POAG).

Materials and methods

In this retrospective case-control study, PLWDs were defined as triangular-shaped defects at the surface of the optic nerve prelaminar tissue, not adjacent to blood vessels, present on cross-sectional SS-OCT scans. Two observers masked to diagnosis independently reviewed scans to detect PLWDs and lamina cribrosa defects. History of disc hemorrhage, occurring within 2 years prior to imaging, was obtained from chart review. One eye per subject was randomly selected. Two-sided t-tests, analysis of variance with Bonferroni correction, and multivariable logistic regression analys

SUBMITTER: Chiou CA 

PROVIDER: S-EPMC8767987 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature