Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants.
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ABSTRACT:
SUBMITTER: van Breemen RB
PROVIDER: S-EPMC8768006 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants.
van Breemen Richard B RB Muchiri Ruth N RN Bates Timothy A TA Weinstein Jules B JB Leier Hans C HC Farley Scotland S Tafesse Fikadu G FG
Journal of natural products 20220110 1
As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection-mass spectrometry was used for the discovery of botanical ligands to the SARS-CoV-2 spike protein. Cannabinoid acids from hemp (<i>Cannabis sativa</i>) were found to be allosteric as well as orthosteric ligands with micromolar affinity for the spike protein. In follow-up ...[more]
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