Ontology highlight
ABSTRACT:
SUBMITTER: Lin CX
PROVIDER: S-EPMC8769916 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Lin Cui-Xiang CX Li Hong-Dong HD Deng Chao C Liu Weisheng W Erhardt Shannon S Wu Fang-Xiang FX Zhao Xing-Ming XM Guan Yuanfang Y Wang Jun J Wang Daifeng D Hu Bin B Wang Jianxin J
Briefings in bioinformatics 20220101 1
Alzheimer's disease (AD) has a strong genetic predisposition. However, its risk genes remain incompletely identified. We developed an Alzheimer's brain gene network-based approach to predict AD-associated genes by leveraging the functional pattern of known AD-associated genes. Our constructed network outperformed existing networks in predicting AD genes. We then systematically validated the predictions using independent genetic, transcriptomic, proteomic data, neuropathological and clinical data ...[more]