Three-dimensional simultaneous brain mapping of T1, T2, T2∗ and magnetic susceptibility with MR Multitasking.

ABSTRACT:

Purpose

To develop a new technique that enables simultaneous quantification of whole-brain T₁ , T₂ , T2∗ , as well as susceptibility and synthesis of six contrast-weighted images in a single 9.1-minute scan.

Methods

The technique uses hybrid T₂ -prepared inversion-recovery pulse modules and multi-echo gradient-echo readouts to collect k-space data with various T1, T2, and T2∗ weightings. The underlying image is represented as a six-dimensional low-rank tensor consisting of three spatial dimensions and three temporal dimensions corresponding to T₁ recovery, T₂ decay, and multi-echo behaviors, respectively. Multiparametric maps were fitted from reconstructed image series. The proposed method was validated on phantoms and h

SUBMITTER: Cao T 

PROVIDER: S-EPMC8776611 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature