The impact of endogenous estrogen exposures on the characteristics and outcomes of estrogen receptor positive, early breast cancer.

ABSTRACT:

Background

Menstrual and parity history might impact the risk for breast cancer. Data on the impact of these factors on other tumor characteristics are limited.

Methods

A single center retrospective cohort study comprising all women with estrogen receptor (ER) positive, human epidermal growth factor receptor 2 (HER2) negative, early breast cancer whose tumors were sent to OncotypeDX analysis. The prespecified subgroups were investigated: age of menarche (< 12 vs. ≥ 12 years), number of deliveries (0 vs. ≥ 1 childbirth and ≥ 5 childbirth vs. other), age of first delivery (≥ 30 years vs. younger age) and postmenopausal compared to premenopausal. The impact of age of menopause was also assessed categorically, using early (< 45 years) and late age of menopause (> 55 years). Diff

SUBMITTER: Korzets Y 

PROVIDER: S-EPMC8777527 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature