SARS-CoV-2 infections in patients with autoimmune blistering disorders: A case series and retrospective analysis.

ABSTRACT:

Background

Autoimmune blistering disorders (AIBDs) are rare, potentially life-threatening conditions often requiring immunosuppression. Throughout the SARS-CoV-2 pandemic, infection risk and mortality in patients with AIBDs are unknown.

Objective

We report the outcomes of SARS-CoV-2 infections in patients with AIBDs and determined if patients on rituximab have an increased risk of SARS-CoV-2 infection.

Methods

We examined clinical outcomes in 10 patients with AIBDs who developed SARS-CoV-2 infections at an American hospital. We performed a retrospective analysis of 132 patients with AIBDs enrolled in a clinical trial.

Results

Patients with severe SARS-CoV-2 (n = 4) or death (n = 2) trended to be older. These patients had higher mortality than the national avera

SUBMITTER: Breglio KF 

PROVIDER: S-EPMC8784432 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature