A Novel Role for Cytochrome P450 Epoxygenase Metabolites in Septic Shock.

ABSTRACT: This is the largest study describing the role of P450 epoxygenase metabolites in septic shock in humans and suggests a novel therapeutic target.

Objectives

Oxylipins are oxidative breakdown products of cell membrane fatty acids. Animal models have demonstrated that oxylipins generated by the P450 epoxygenase pathway may be implicated in septic shock pathology. However, these mediators are relatively unexplored in humans with septic shock. We aimed to determine if there were patterns of oxylipins that were associated with 28-day septic shock mortality and organ dysfunction.

Design

Retrospective analysis of samples collected during the Vasopressin versus Norepinephrine as Initial Therapy in Septic Shock trial.

Setting

ICUs in the United Kingdom.

Participants

Adult

SUBMITTER: Jones TN 

PROVIDER: S-EPMC8785925 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature