Phenotypic clusters and survival analyses in interstitial pneumonia with myositis-specific autoantibodies.

ABSTRACT:

Background

Idiopathic inflammatory myopathy (IIM) is highly combined with interstitial pneumonia (IP), often as the initial or solo presentation with positive myositis-specific autoantibodies (MSAs) but does not fulfill the diagnostic criteria.

Objectives

We aimed to explore the phenotypic clusters and prognosis of the patients with IP and positive MSA, which is called MSA-IP in the present study.

Methods

A total of 178 patients with MSA-IP were prospectively enrolled for analysis. Serum MSAs were detected using Western blotting. Radiological patterns of IP were determined according to the classification of idiopathic IPs. Clusters of patients with MSA-IP were identified using cluster analysis. Predictors for acute/subacute onset, therapeutic response, IP progression

SUBMITTER: Lia Y 

PROVIDER: S-EPMC8787374 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature