Placental miR-3940-3p Is Associated With Maternal Insulin Resistance in Late Pregnancy.

ABSTRACT:

Context

An increase in maternal insulin resistance (IR) during pregnancy is essential for normal fetal growth. The mechanisms underlying this adaptation are poorly understood. Placental factors are believed to instigate and maintain these changes, as IR decreases shortly after delivery. Methylation of placental gene loci that are common targets for miRNAs are associated with maternal IR.

Objective

We hypothesized that placental miRNAs targeting methylated loci are associated with maternal IR during late pregnancy.

Methods

We collected placentas from 132 elective cesarean sections and fasting blood samples at delivery to estimate maternal homeostasis model assessment of insulin resistance (HOMA-IR). Placental miRNA expression was measured via whole genome small-RNA seq

SUBMITTER: Alvarado-Flores F 

PROVIDER: S-EPMC8787748 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature