Unknown

Dataset Information

0

Association of acidic urine pH with impaired renal function in primary gout patients: a Chinese population-based cross-sectional study.


ABSTRACT:

Background

Patients with gout frequently have low urinary pH, which is associated with the nephrolithiasis. However, the specific distribution of urinary pH and potential relationship of acidic urine pH to broader manifestations of kidney disease in gout are still poorly understood.

Methods

A 2016-2020 population-based cross-sectional study was conducted among 3565 gout patients in the dedicated gout clinic of the Affiliated Hospital of Qingdao University to investigate the association between low urinary pH and kidney disease. We studied patients that we defined to have "primary gout", based on the absence of > stage 2 CKD. All subjects underwent 14 days of medication washout and 3-day standardized metabolic diet. We obtained general medical information, blood and urine biochemistries, and renal ultrasound examination on the day of the visit. The primary readouts were urine pH, eGFR, nephrolithiasis, renal cysts, microhematuria, and proteinuria. Patients were assigned into 5 subgroups (urine pH ≤5.0, 5.0 6.9), aligning with the clinical significance of urine pH.

Results

Overall, the median urine pH and eGFR of all patients was 5.63 (IQR 5.37~6.09), and 98.32 (IQR 86.03~110.6), with acidic urine in 46.5% of patients. The prevalence of nephrolithiasis, microhematuria, and proteinuria were 16.9%, 49.5%, and 6.9%, respectively. By univariate analysis, eGFR was significantly associated with age, sex, duration of gout, tophus, body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, total cholesterol, serum utare, hypertension, diabetes, and urine pH. On multivariable analysis, eGFR was associated with age, sex, diastolic blood pressure, serum uric acid, hypertension, diabetes, and urine pH. Acidic urine pH, especially urine pH < 5.0, was significantly associated with the prevalence of kidney disease, including > stage 1 CKD, nephrolithiasis, kidney cyst, and microhematuria. Patients with 6.2 ≤ urine pH ≤ 6.9 and SU ≤ 480 μmol/L had the highest eGFR with the lowest prevalence of nephrolithiasis, microhematuria, and proteinuria.

Conclusions

Approximately half of gout subjects had acidic urine pH. Urine pH < 5.0 was associated with significantly increased nephrolithiasis, renal cyst, microhematuria, and proteinuria. The results support prospective clinical investigation of urinary alkalinization in selected gout patients with acidic urine pH.

SUBMITTER: He Y 

PROVIDER: S-EPMC8787907 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Association of acidic urine pH with impaired renal function in primary gout patients: a Chinese population-based cross-sectional study.

He Yuwei Y   Xue Xiaomei X   Terkeltaub Robert R   Dalbeth Nicola N   Merriman Tony R TR   Mount David B DB   Feng Zhe Z   Li Xinde X   Cui Lingling L   Liu Zhen Z   Xu Yan Y   Chen Ying Y   Li Hailong H   Ji Aichang A   Ji Xiaopeng X   Wang Xuefeng X   Lu Jie J   Li Changgui C  

Arthritis research & therapy 20220125 1


<h4>Background</h4>Patients with gout frequently have low urinary pH, which is associated with the nephrolithiasis. However, the specific distribution of urinary pH and potential relationship of acidic urine pH to broader manifestations of kidney disease in gout are still poorly understood.<h4>Methods</h4>A 2016-2020 population-based cross-sectional study was conducted among 3565 gout patients in the dedicated gout clinic of the Affiliated Hospital of Qingdao University to investigate the associ  ...[more]

Similar Datasets

| S-EPMC5134876 | biostudies-literature
| S-EPMC5638318 | biostudies-literature
2024-09-17 | GSE277296 | GEO
| S-EPMC10513105 | biostudies-literature
| S-EPMC11772953 | biostudies-literature
| S-EPMC11696702 | biostudies-literature
| S-EPMC8566261 | biostudies-literature
| S-EPMC6879116 | biostudies-literature
| S-EPMC5733879 | biostudies-literature
| PRJEB50407 | ENA