The influence of comorbidities on achieving an N-terminal pro-b-type natriuretic peptide target: a secondary analysis of the GUIDE-IT trial.

ABSTRACT:

Aims

N-terminal pro-b-type natriuretic peptide (NT-proBNP) values may be influenced by patient factors beyond the severity of illness, including atrial fibrillation (AF), renal dysfunction, or increased body mass index (BMI). We hypothesized that these factors may influence the achievement of NT-proBNP targets and clinical outcomes.

Methods

A total of 894 patients with heart failure with reduced ejection fraction were enrolled in The Guiding Evidence-Based Therapy Using Biomarker Intensified Treatment trial. NT-proBNP was analysed every 3 months.

Results

Forty per cent of patients had AF, the median estimated glomerular filtration rate (eGFR) was 59 mL/min/1.73 m² [interquartile range (IQR) 43-76], and median BMI was 29 kg/m² (IQR 25-34). Patient

SUBMITTER: Ezekowitz JA 

PROVIDER: S-EPMC8787989 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature