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Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles.

ABSTRACT:

Background

SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory.

Aim of the study

To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor.

Methods

SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations.

Results

Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to promote the rupture of SARS-CoV-2 VLP membranes.

Conclusion

Including CPC in mouthwashes could be a prophylactic strategy to keep SARS-CoV-2 from spreading.

SUBMITTER: Bano-Polo M

PROVIDER: S-EPMC8788378 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Cetylpyridinium chloride promotes disaggregation of SARS-CoV-2 virus-like particles.

Bañó-Polo Manuel M Martínez-Gil Luis L Sánchez Del Pino Manuel M MM Massoli Alberto A Mingarro Ismael I Léon Rubén R Garcia-Murria Maria Jesus MJ

Journal of oral microbiology 20220124 1

<h4>Background</h4>SARS-CoV-2 is continuously disseminating worldwide. The development of strategies to break transmission is mandatory.<h4>Aim of the study</h4>To investigate the potential of cetylpyridinium chloride (CPC) as a viral inhibitor.<h4>Methods</h4>SARS-CoV-2 Virus Like-Particles (VLPs) were incubated with CPC, a potent surfactant routinely included in mouthwash preparations.<h4>Results</h4>Concentrations of 0.05% CPC (w/v) commonly used in mouthwash preparations are sufficient to pr ...[more]

PMID: 35087641

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