Ontology highlight
ABSTRACT:
SUBMITTER: Malina J
PROVIDER: S-EPMC8789045 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Malina Jaroslav J Kostrhunova Hana H Novohradsky Vojtech V Scott Peter P Brabec Viktor V
Nucleic acids research 20220101 2
The design of efficient and safe gene delivery vehicles remains a major challenge for the application of gene therapy. Of the many reported gene delivery systems, metal complexes with high affinity for nucleic acids are emerging as an attractive option. We have discovered that certain metallohelices-optically pure, self-assembling triple-stranded arrays of fully encapsulated Fe-act as nonviral DNA delivery vectors capable of mediating efficient gene transfection. They induce formation of globula ...[more]