Total Nephron Number and Single-Nephron Parameters in Patients with IgA Nephropathy.

ABSTRACT:

Background

Single-nephron dynamics in progressive IgA nephropathy (IgAN) have not been studied. We applied novel methodology to explore single-nephron parameters in IgAN.

Methods

Nonglobally sclerotic glomeruli (NSG) and globally sclerotic glomeruli (GSG) per kidney were estimated using cortical volume assessment via unenhanced computed tomography and biopsy-based stereology. Estimated single-nephron GFR (eSNGFR) and single-nephron urine protein excretion (SNUPE) were calculated by dividing eGFR and UPE by the number of NSG. Associations with CKD stage and clinicopathologic findings were cross-sectionally investigated.

Results

This study included 245 patients with IgAN (mean age 43 years, 62% male, 45% on renin-angiotensin aldosterone system [RAAS] inhibitors p

SUBMITTER: Marumoto H 

PROVIDER: S-EPMC8791345 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature