In vitro evaluation of a novel oxygen-generating biomaterial for chronic rhinosinusitis therapy.

ABSTRACT:

Background

Hypoxia due to closure at the ostiomeatal complex is widely considered one of the major pathogenic mechanisms leading to chronic inflammation in chronic rhinosinusitis (CRS). The objective of this study was to develop and characterize an oxygen-generating biomaterial (OGB) as an innovative treatment strategy for CRS.

Methods

An OGB was fabricated by coating hydrophobic beeswax (BW, 15mg or 30mg) on the surface of calcium peroxide - catalase complex (CPO-CA, 30mg) and characterized using scanning electron microscopy (SEM). In vitro releases of both oxygen and hydrogen peroxide (H₂ O₂ ) were spectrophotometrically quantified, and cytotoxicity in human sinonasal epithelial cells (HSNECs) was evaluated. The influence of OGB on transepithelial Cl<

SUBMITTER: Lim DJ 

PROVIDER: S-EPMC8792167 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature