Ontology highlight
ABSTRACT:
SUBMITTER: Fielding C
PROVIDER: S-EPMC8795384 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Fielding Claire C García-García Andrés A Korn Claudia C Gadomski Stephen S Fang Zijian Z Reguera Juan L JL Pérez-Simón José A JA Göttgens Berthold B Méndez-Ferrer Simón S
Nature communications 20220127 1
The sympathetic nervous system has been evolutionary selected to respond to stress and activates haematopoietic stem cells via noradrenergic signals. However, the pathways preserving haematopoietic stem cell quiescence and maintenance under proliferative stress remain largely unknown. Here we found that cholinergic signals preserve haematopoietic stem cell quiescence in bone-associated (endosteal) bone marrow niches. Bone marrow cholinergic neural signals increase during stress haematopoiesis an ...[more]