Red blood cell transfusions in preterm newborns and neurodevelopmental outcomes at 2 and 5 years of age.

ABSTRACT:

Background

Red blood cell (RBC) transfusion is often considered a life-saving measure in preterm neonates. However, it has been associated with detrimental effects on short-term morbidities and, recently, on brain development. The aim of the present study was to evaluate the association between RBC and long-term neurodevelopmental outcome in a cohort of preterm infants.

Materials and methods

This retrospective cohort study was carried out in the period 2007-2013. Preterm infants with a gestational age (GA) ≤ 32 weeks and birthweight (BW) <1,500 g were included. Infants underwent Griffiths assessment at 24±6 months corrected age (CA) and at 5±1 years of age. We used a multivariate regression model to assess the association of RBC transfusions and long-term neurodevelopment af

SUBMITTER: Fontana C 

PROVIDER: S-EPMC8796841 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature