Lung- and Diaphragm-Protective Ventilation by Titrating Inspiratory Support to Diaphragm Effort: A Randomized Clinical Trial.

ABSTRACT:

Objectives

Lung- and diaphragm-protective ventilation is a novel concept that aims to limit the detrimental effects of mechanical ventilation on the diaphragm while remaining within limits of lung-protective ventilation. The premise is that low breathing effort under mechanical ventilation causes diaphragm atrophy, whereas excessive breathing effort induces diaphragm and lung injury. In a proof-of-concept study, we aimed to assess whether titration of inspiratory support based on diaphragm effort increases the time that patients have effort in a predefined "diaphragm-protective" range, without compromising lung-protective ventilation.

Design

Randomized clinical trial.

Setting

Mixed medical-surgical ICU in a tertiary academic hospital in the Netherlands.

Patients

SUBMITTER: de Vries HJ 

PROVIDER: S-EPMC8797006 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature