Fecal Microbiota Transplantation Commonly Failed in Children With Co-Morbidities.

ABSTRACT:

Objectives

Fecal microbiota transplantation (FMT) is arguably the most effective treatment for recurrent Clostridioides difficile infection (rCDI). Clinical reports on pediatric FMT have not systematically evaluated microbiome restoration in patients with co-morbidities. Here, we determined whether FMT recipient age and underlying co-morbidity influenced clinical outcomes and microbiome restoration when treated from shared fecal donor sources.

Methods

Eighteen rCDI patients participating in a single-center, open-label prospective cohort study received fecal preparation from a self-designated (single case) or two universal donors. Twelve age-matched healthy children and four pediatric ulcerative colitis (UC) cases from an independent serial FMT trial, but with a shared fecal

SUBMITTER: Kellermayer R 

PROVIDER: S-EPMC8799498 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature