Analysis of Association between Morphometric Parameters of Growth Plate and Bone Growth of Tibia in Mice and Humans.

ABSTRACT:

Objective

The purposes of this study are to evaluate which growth plate parameters are associated with bone growth in mice and to compare the mouse results with those in humans.

Design

The sagittal sections of the proximal growth plate of the mouse tibia from neonate to young adult stages were subjected to histomorphometric and functional analyses. The radiographic images of tibias of human patients until puberty were analyzed to obtain the tibia length and the proximal growth plate height. It was found that a linear correlation best modeled the relationship between the growth plate variables with the tibia growth rate and length.

Results

In mice, total height, resting zone height, combined height of the proliferation and prehypertrophic zones, proliferation activity,

SUBMITTER: Wilson K 

PROVIDER: S-EPMC8804827 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature