Intravenous thrombolysis in ischemic stroke patients with a prior intracranial hemorrhage: a meta-analysis.

ABSTRACT:

Background

The history of intracranial hemorrhage (ICrH) is considered a contraindication for intravenous thrombolysis (IVT) among patients with acute ischemic stroke (AIS). Objective: This study aimed at comparing the safety of IVT among patients with and without a history of ICrH.

Methods

We performed a systematic review of the literature. Data regarding all AIS patients with prior ICrH who received IVT were retrieved. Meta-analysis was performed to compare the rate of symptomatic hemorrhagic transformation (sHT), death within 90 days, and favorable and unfavorable 90-day functional outcomes based on modified Rankin Scale (mRS) among stroke patients with and without prior ICrH.

Results

Out of 13,032 reviewed records, 7 studies were included in the systematic review

SUBMITTER: Dolatshahi M 

PROVIDER: S-EPMC8808019 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature