Cardiorespiratory alterations in a newborn ovine model of systemic viral inflammation.

ABSTRACT:

Background

Respiratory viruses can be responsible for severe apneas and bradycardias in newborn infants. The link between systemic inflammation with viral sepsis and cardiorespiratory alterations remains poorly understood. We aimed to characterize these alterations by setting up a full-term newborn lamb model of systemic inflammation using polyinosinic:polycytidylic acid (Poly I:C).

Methods

Two 6-h polysomnographic recordings were carried out in eight lambs on two consecutive days, first after an IV saline injection, then after an IV injection of 300 μg/kg Poly I:C.

Results

Poly I:C injection decreased locomotor activity and increased NREM sleep. It also led to a biphasic increase in rectal temperature and heart rate. The latter was associated with an overall decrease

SUBMITTER: Nault S 

PROVIDER: S-EPMC8809061 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature