Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC8809507 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Zhang Zhuo Z Luo Lin L Xing Chuan C Chen Yu Y Xu Peng P Li Mao M Zeng Ling L Li Chao C Ghosh Sadashib S Della Manna Deborah D Townes Tim T Britt William J WJ Wajapeyee Narendra N Sleckman Barry P BP Chong Zechen Z Leavenworth Jianmei Wu JW Yang Eddy S ES
Nature cancer 20211022 10
Expanding the utility of immune-based cancer treatments is a clinical challenge due to tumor-intrinsic factors that suppress the immune response. Here we report the identification of tumoral ring finger protein 2 (RNF2), the core subunit of polycomb repressor complex 1, as a negative regulator of antitumor immunity in various human cancers, including breast cancer. In syngeneic murine models of triple-negative breast cancer, we found that deleting genes encoding the polycomb repressor complex 1 ...[more]