Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort.

ABSTRACT:

Introduction

To examine the independent association of body mass index (BMI) in early adulthood with dementia incidence among men and women.

Methods

We studied 5104 older adults from the Cardiovascular Health Study (CHS) and the Health, Aging, and Body Composition (Health ABC) study. We imputed early adulthood and midlife BMI using a pooled parent cohort with complete adult lifespan coverage and previously established methods. Dementia was ascertained using criteria such as neuropsychological test battery, medical records, and dementia-related drug use. Pooled logistic regression (PLR) models were used.

Results

Compared to women with normal BMI in early adulthood, the odds of dementia were higher among both overweight (odds ratio [OR] = 1.8; 95% confidence interval [C

SUBMITTER: Zeki Al Hazzouri A 

PROVIDER: S-EPMC8809510 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature