Dataset Information
Depression and Apathy across Different Variants of Progressive Supranuclear Palsy.
Ontology highlight
ABSTRACT: Background
Apathy and depression commonly occur in patients with progressive supranuclear palsy (PSP)-Richardson's syndrome variant; depression often requiring treatment. Little is known, however, about apathy and depression among other PSP variants.Methods
We prospectively studied 97 newly diagnosed PSP patients. All were classified into a PSP variant using the 2017 Movement Disorder Society-PSP criteria and administered the Geriatric Depression and Apathy Evaluation Scales. Differences in apathy and depression frequency and severity across six variants, and secondarily across PSP-Richardson's syndrome, PSP-Cortical and PSP-Subcortical, were analyzed using ANCOVA and linear regression adjusting for disease severity.Results
Depression (55%) was more common than apathy (12%). PSP-Speech/Language (PSP-SL) variant had the lowest depression frequency (13%) and lower depression scores than the other variants. No differences in apathy frequency/severity were identified.Conclusion
PSP-SL patients may have less depression compared to PSP-Richardson's syndrome and other PSP variants.
SUBMITTER: Bower SM
PROVIDER: S-EPMC8810431 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Depression and Apathy across Different Variants of Progressive Supranuclear Palsy.
Movement disorders clinical practice 20211231 2
<h4>Background</h4>Apathy and depression commonly occur in patients with progressive supranuclear palsy (PSP)-Richardson's syndrome variant; depression often requiring treatment. Little is known, however, about apathy and depression among other PSP variants.<h4>Methods</h4>We prospectively studied 97 newly diagnosed PSP patients. All were classified into a PSP variant using the 2017 Movement Disorder Society-PSP criteria and administered the Geriatric Depression and Apathy Evaluation Scales. Dif ...[more]
