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Intertissue mechanical interactions shape the olfactory circuit in zebrafish.

ABSTRACT: While the chemical signals guiding neuronal migration and axon elongation have been extensively studied, the influence of mechanical cues on these processes remains poorly studied in vivo. Here, we investigate how mechanical forces exerted by surrounding tissues steer neuronal movements and axon extension during the morphogenesis of the olfactory placode in zebrafish. We mainly focus on the mechanical contribution of the adjacent eye tissue, which develops underneath the placode through extensive evagination and invagination movements. Using quantitative analysis of cell movements and biomechanical manipulations, we show that the developing eye exerts lateral traction forces on the olfactory placode through extracellular matrix, mediating proper morphogenetic movements and axon extension within the placode. Our data shed new light on the key participation of intertissue mechanical interactions in the sculpting of neuronal circuits.

SUBMITTER: Monnot P

PROVIDER: S-EPMC8811657 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Intertissue mechanical interactions shape the olfactory circuit in zebrafish.

Monnot Pauline P Gangatharan Girisaran G Baraban Marion M Pottin Karen K Cabrera Melody M Bonnet Isabelle I Breau Marie Anne MA

EMBO reports 20211209 2

While the chemical signals guiding neuronal migration and axon elongation have been extensively studied, the influence of mechanical cues on these processes remains poorly studied in vivo. Here, we investigate how mechanical forces exerted by surrounding tissues steer neuronal movements and axon extension during the morphogenesis of the olfactory placode in zebrafish. We mainly focus on the mechanical contribution of the adjacent eye tissue, which develops underneath the placode through extensiv ...[more]

PMID: 34889034

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