Restoration of miR-223-3p expression in aged mouse uteri with Samul-tang administration.

ABSTRACT:

Background

During the secretory phase of the estrous cycle, endometrium senescence is accompanied by biological mechanisms such as metabolic dysfunction and epigenetic changes, leading to decreased embryo receptivity and implantation failure. Samul-tang has been reported to improve implantation potential in aged mice.

Methods

To uncover the age-related changes in the transcriptomes, we performed QuantSeq 3'mRNA sequencing to compare the mRNA expression patterns in the uteri between young and old mice. Young and old female BALB/c mice were administered distilled water or Samul-tang for 4 weeks, and the corresponding effects on the uteri of aged mice were investigated.

Results

We found 586 differentially expressed genes between the young and old mouse groups. Functional

SUBMITTER: Kim J 

PROVIDER: S-EPMC8814392 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature