From GWAS to drug screening: repurposing antipsychotics for glioblastoma.

ABSTRACT:

Background

Glioblastoma is currently an incurable cancer. Genome-wide association studies have demonstrated that 41 genetic variants are associated with glioblastoma and may provide an option for drug development.

Methods

We investigated FDA-approved antipsychotics for their potential treatment of glioblastoma based on genome-wide association studies data using a 'pathway/gene-set analysis' approach.

Results

The in-silico screening led to the discovery of 12 candidate drugs. DepMap portal revealed that 42 glioma cell lines show higher sensitivities to 12 candidate drugs than to Temozolomide, the current standard treatment for glioblastoma.

Conclusion

In particular, cell lines showed significantly higher sensitivities to Norcyclobenzaprine and Protriptyline whic

SUBMITTER: Lin WZ 

PROVIDER: S-EPMC8815269 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature