Multidimensional Dynamics of the Proteome in the Neurodegenerative and Aging Mammalian Brain.
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ABSTRACT:
SUBMITTER: Andrews B
PROVIDER: S-EPMC8816717 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Multidimensional Dynamics of the Proteome in the Neurodegenerative and Aging Mammalian Brain.
Andrews Byron B Murphy Alan E AE Stofella Michele M Maslen Sarah S Almeida-Souza Leonardo L Skehel J Mark JM Skene Nathan G NG Sobott Frank F Frank René A W RAW
Molecular & cellular proteomics : MCP 20211231 2
The amount of any given protein in the brain is determined by the rates of its synthesis and destruction, which are regulated by different cellular mechanisms. Here, we combine metabolic labeling in live mice with global proteomic profiling to simultaneously quantify both the flux and amount of proteins in mouse models of neurodegeneration. In multiple models, protein turnover increases were associated with increasing pathology. This method distinguishes changes in protein expression mediated by ...[more]
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