Eight-week multi-domain cognitive training does not impact large-scale resting-state brain networks in Parkinson's disease.

ABSTRACT: There is meta-analytic evidence for the efficacy of cognitive training (CT) in Parkinson's disease (PD). We performed a randomized controlled trial where we found small positive effects of CT on executive function and processing speed in individuals with PD (n_total = 140). In this study, we assessed the effects of CT on brain network connectivity and topology in a subsample of the full study population (n_mri = 86). Participants were randomized into an online multi-domain CT and an active control condition and performed 24 sessions of either intervention in eight weeks. Resting-state functional MRI scans were acquired in addition to extensive clinical and neuropsychological assessments pre- and post-intervention. In line with our preregistered analysis plan (osf.io/3st

SUBMITTER: van Balkom TD 

PROVIDER: S-EPMC8819471 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature