Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease.

ABSTRACT: We review progress towards greater mechanistic understanding and clinical translation of a strategy to improve respiratory and non-respiratory motor function in people with neuromuscular disorders, therapeutic acute intermittent hypoxia (tAIH). In 2016 and 2020, workshops to create and update a "road map to clinical translation" were held to help guide future research and development of tAIH to restore movement in people living with chronic, incomplete spinal cord injuries. After briefly discussing the pioneering, non-targeted basic research inspiring this novel therapeutic approach, we then summarize workshop recommendations, emphasizing critical knowledge gaps, priorities for future research effort, and steps needed to accelerate progress as we evaluate the potential of tAIH for routine

SUBMITTER: Vose AK 

PROVIDER: S-EPMC8820239 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature