Dataset Information

A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol.

ABSTRACT:

Background

Acute leukaemias (AL) are aggressive but potentially curable blood cancers that can potentially affect women of childbearing age. When a pregnancy is complicated by a diagnosis of AL, clinicians face a complex dilemma: to balance risking the mother's survival through delayed AL treatment, against the potential harm to the foetus through exposure to anti-cancer drugs. Up until now, all guidance and advice regarding the management of AL in pregnancy, have been based on expert opinion and small case studies. There is a pressing need for more studies in the subject to address this evidence gap.

Methods and analysis

This study is a registry-based observational cohort study which aims to monitor and record the treatment outcomes of patients diagnosed with AL during pregnancy. Additionally, the study aims to assess pregnancy outcomes in patients who become pregnant following successful treatment. Prospective and historical cases from August 2009 onwards will be identified from AL treating haematology units within the UK. Details of diagnosis, AL treatment delivered, antenatal and postnatal outcomes for mother and neonate will be collected. This study will establish a new research database for Leukaemia in Pregnancy.

Trial registration

The study was registered on Clinicaltrials.gov (NCT04182074) on the 2nd December 2019.

SUBMITTER: Northgraves M

PROVIDER: S-EPMC8820608 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol.

Northgraves Matthew M Allsup David D Cohen Judith J Huang Chao C Turgoose John J Ali Sahra S

PloS one 20220207 2

<h4>Background</h4>Acute leukaemias (AL) are aggressive but potentially curable blood cancers that can potentially affect women of childbearing age. When a pregnancy is complicated by a diagnosis of AL, clinicians face a complex dilemma: to balance risking the mother's survival through delayed AL treatment, against the potential harm to the foetus through exposure to anti-cancer drugs. Up until now, all guidance and advice regarding the management of AL in pregnancy, have been based on expert op ...[more]

PMID: 35130292

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Dataset Information

A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol.

Background

Methods and analysis

Trial registration

Publications

A prospective registry-based cohort study of the diagnosis and management of acute leukaemia in pregnancy: Study protocol.

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