Pesticide residue intake from fruits and vegetables and alterations in the serum metabolome of women undergoing infertility treatment.

ABSTRACT:

Background

Pesticide exposure is linked to a myriad of negative health effects; however, the mechanisms underlying these associations are less clear. We utilized metabolomics to describe the alterations in the serum metabolome associated with high and low pesticide residue intake from fruits and vegetables (FVs), the most common route of exposure in humans.

Methods

This analysis included 171 women undergoing in vitro fertilization who completed a validated food frequency questionnaire and provided a serum sample during controlled ovarian stimulation (2007-2015). FVs were categorized as high or low-to-moderate pesticide residue using a validated method based on pesticide surveillance data from the USDA. We conducted untargeted metabolic profiling using liquid chromatography w

SUBMITTER: Hood RB 

PROVIDER: S-EPMC8821142 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature