Length of PM_2.5 exposure and alterations in the serum metabolome among women undergoing infertility treatment.

ABSTRACT:

Background

Both acute and chronic exposure to fine particulate matter (PM_2.5) have been linked to negative health outcomes. Studies have used metabolomics to describe the biological pathways linking PM_2.5 with disease but have focused on a single exposure window. We compared alterations in the serum metabolome following various short- and long-term PM_2.5 exposures.

Methods

Participants were women undergoing in vitro fertilization at a New England fertility clinic (n = 200). Women provided their residential address and provided a blood sample during controlled ovarian stimulation. PM_2.5 exposure was estimated in the 1, 2, and 3 days, 2 weeks, and 3 months prior to blood collection using a validated spatiotemporal model. We ut

SUBMITTER: Hood RB 

PROVIDER: S-EPMC8835541 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature