Flat Pattern Peaks of Tacrolimus Absorption and Associated Pharmacogenomic Variants in Kidney Transplantation Recipients.

ABSTRACT:

Background

Tacrolimus is the most commonly used immunosuppressive drug in solid organ transplantation. After administering a conventional twice-daily dose of tacrolimus, peak levels were achieved within the first 1.5 to 2 hours. A group of patients showed different early absorption phase of tacrolimus after kidney transplantation.

Methods

Trough(C₀) and 1.5-hour blood levels (C_1.5) of tacrolimus were measured in 95 kidney transplantation recipients. Patients with a C_1.5/C₀ < 1.5 and > 1.5 were defined as those having flat pattern peaks and as controls, respectively. Transplantation outcomes were compared between the groups. Whole exome sequencing was performed to investigate the genetic susceptibility to flat pattern peaks.

Resu

SUBMITTER: Kim SM 

PROVIDER: S-EPMC8822115 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature