Genetic Characteristics and Microbiological Profile of Hypermucoviscous Multidrug-Resistant Klebsiella variicola Coproducing IMP-4 and NDM-1 Carbapenemases.

ABSTRACT: We report here a hypermucoviscous, New Delhi metallo-β-lactamase 1 (NDM-1) and imipenemase 4 (IMP-4) carbapenemases-coproducing Klebsiella variicola isolate obtained from a pediatric patient. This strain was resistant to carbapenems and most other β-lactams. Although hypermucoviscous, this strain possessed attenuated virulence according to serum killing assay and Galleria mellonella infection model. Notably, two copies of bla_NDM-1 were contained on two tandem ISCR1 elements and coexisted with bla_IMP-4 in a novel hybrid multidrug resistance plasmid. This is the first description of the coexistence of bla_NDM-1 and bla_IMP-4 in a single plasmid of hypermucoviscous K. variicola. IMPORTANCE As an important memb

SUBMITTER: Wang B 

PROVIDER: S-EPMC8823660 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature