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Electrochemical [4 + 1] Tandem sp³(C-H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines.

ABSTRACT: 3-Acyl imidazo[1,5-a]pyridines, featured pharmaceutical moieties that were prepared by a three-step reaction conventionally, could be obtained in one step by an electrochemical tandem sp³ (C-H) double amination of acetophenones with pyridine ethylamines using ammonium iodide as a redox mediator.

SUBMITTER: Wang Q

PROVIDER: S-EPMC8829863 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Electrochemical [4 + 1] Tandem sp3(C-H) Double Amination for the Direct Synthesis of 3-Acyl-Functionalized Imidazo[1,5-a]pyridines.

Wang Qiang Q Yao Xia X Xu Xian-Jing XJ Zhang Shuai S Ren Lei L

ACS omega 20220127 5

3-Acyl imidazo[1,5-a]pyridines, featured pharmaceutical moieties that were prepared by a three-step reaction conventionally, could be obtained in one step by an electrochemical tandem sp3 (C-H) double amination of acetophenones with pyridine ethylamines using ammonium iodide as a redox mediator. ...[more]

PMID: 35155923

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