Study on diverse pathological characteristics of heart failure in different stages based on proteomics.
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ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC8831959 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
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Study on diverse pathological characteristics of heart failure in different stages based on proteomics.
Liu Jinying J Lian Hongjian H Yu Jiang J Wu Jie J Chen Xiangyang X Wang Peng P Tian Lei L Yang Yunfei Y Yang Jiaqi J Li Dong D Guo Shuzhen S
Journal of cellular and molecular medicine 20220119 4
Heart failure is a process characterized by significant disturbance of protein turnover. To elucidate the alterations in cardiac protein expression during the various phases of heart failure and to understand the nature of the processes involved, we analysed the proteome in an established heart failure model at different time points to monitor thousands of different proteins simultaneously. Here, heart failure was induced by transverse aortic constriction (TAC) in KM mice. At 2, 4 and 12 weeks a ...[more]
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