Extracellular electron transfer increases fermentation in lactic acid bacteria via a hybrid metabolism.

ABSTRACT: Energy conservation in microorganisms is classically categorized into respiration and fermentation; however, recent work shows some species can use mixed or alternative bioenergetic strategies. We explored the use of extracellular electron transfer for energy conservation in diverse lactic acid bacteria (LAB), microorganisms that mainly rely on fermentative metabolism and are important in food fermentations. The LAB Lactiplantibacillus plantarum uses extracellular electron transfer to increase its NAD⁺/NADH ratio, generate more ATP through substrate-level phosphorylation, and accumulate biomass more rapidly. This novel, hybrid metabolism is dependent on a type-II NADH dehydrogenase (Ndh2) and conditionally requires a flavin-binding extracellular lipoprotein (PplA) under l

SUBMITTER: Tejedor-Sanz S 

PROVIDER: S-EPMC8837199 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature