Reactive Magnetron Plasma Modification of Electrospun PLLA Scaffolds with Incorporated Chloramphenicol for Controlled Drug Release.

ABSTRACT: Surface modification with the plasma of the direct current reactive magnetron sputtering has demonstrated its efficacy as a tool for enhancing the biocompatibility of polymeric electrospun scaffolds. Improvement of the surface wettability of materials with water, as well as the formation of active chemical bonds in the near-surface layers, are the main reasons for the described effect. These surface effects are also known to increase the release rate of drugs incorporated in fibers. Herein, we investigated the effect of plasma modification on the chloramphenicol release from electrospun poly (lactic acid) fibrous scaffolds. Scaffolds with high-50 wt./wt.%-drug content were obtained. It was shown that plasma modification leads to an increase in the drug release rate and drug diffusion coeff

SUBMITTER: Volokhova AA 

PROVIDER: S-EPMC8839200 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature