Dataset Information

Long-term diosmectite use does not alter the gut microbiota in adults with chronic diarrhea.

ABSTRACT:

Background

Diosmectite, a natural colloidal clay, has been used worldwide for a number of approved indications, including the treatment of chronic functional diarrhea. Here, we used high-resolution whole metagenome shotgun sequencing to assess the impact of a 5 weeks administration of diosmectite (3 g/sachet, 3 sachets/day) on the fecal microbiota of 35 adults with functional chronic diarrhea.

Results

Gut microbiota was not impacted by diosmectite administration. In particular, richness remained stable and no microbial species displayed a significant evolution. Segregating patients either by diosmectite response (non responder, early responder, late responder) or by nationality (Great-Britain or Netherlands) yielded the same results.

Conclusion

We concluded that no microbiota-related physiological alterations are expected upon long-term treatment with diosmectite.

Trial registration

Clinicaltrials.gov NCT03045926.

SUBMITTER: Da Silva K

PROVIDER: S-EPMC8840705 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Publications

Long-term diosmectite use does not alter the gut microbiota in adults with chronic diarrhea.

Da Silva Kévin K Guilly Susie S Thirion Florence F Le Chatelier Emmanuelle E Pons Nicolas N Roume Hugo H Quinquis Benoît B Ehrlich Stanislav D SD Bekkat Nassima N Mathiex-Fortunet Hélène H Sokol Harry H Doré Joël J

BMC microbiology 20220212 1

<h4>Background</h4>Diosmectite, a natural colloidal clay, has been used worldwide for a number of approved indications, including the treatment of chronic functional diarrhea. Here, we used high-resolution whole metagenome shotgun sequencing to assess the impact of a 5 weeks administration of diosmectite (3 g/sachet, 3 sachets/day) on the fecal microbiota of 35 adults with functional chronic diarrhea.<h4>Results</h4>Gut microbiota was not impacted by diosmectite administration. In particular, ri ...[more]

PMID: 35151268

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Dataset Information

Long-term diosmectite use does not alter the gut microbiota in adults with chronic diarrhea.

Background

Results

Conclusion

Trial registration

Publications

Long-term diosmectite use does not alter the gut microbiota in adults with chronic diarrhea.

Similar Datasets

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