Challenging the negative learning bias hypothesis of depression: reversal learning in a naturalistic psychiatric sample.

ABSTRACT:

Background

Classic theories posit that depression is driven by a negative learning bias. Most studies supporting this proposition used small and selected samples, excluding patients with comorbidities. However, comorbidity between psychiatric disorders occurs in up to 70% of the population. Therefore, the generalizability of the negative bias hypothesis to a naturalistic psychiatric sample as well as the specificity of the bias to depression, remain unclear. In the present study, we tested the negative learning bias hypothesis in a large naturalistic sample of psychiatric patients, including depression, anxiety, addiction, attention-deficit/hyperactivity disorder, and/or autism. First, we assessed whether the negative bias hypothesis of depression generalized to a heterogeneous (an

SUBMITTER: Brolsma SCA 

PROVIDER: S-EPMC8842187 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature