TNFAIP3 alleviates pain in lumbar disc herniation rats by inhibiting the NF-κB pathway.

ABSTRACT:

Background

It's been reported that the tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene played an important role in the pathogenesis of autoimmune and chronic inflammation diseases. Moreover, in degenerative diseases of the lumbar spine the nuclear factor-κB (NF-κB) pathway is significantly activated. This study aimed to explore the role of the tumor necrosis protein-induced zinc finger protein A20 (A20) protein in degenerative diseases of the lumbar spine on the NF-κBp65 pathway.

Methods

A total of 96 rats were randomly divided into 4 groups. Lumbar disc herniation (DH) was set as a sham operation group (Sham group), DH + A20 group and DH + control group (Control group); measured changes in rat paw withdrawal threshold (PWT) and paw withdrawal latency (

SUBMITTER: Xie Z 

PROVIDER: S-EPMC8848453 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature