Dataset Information

The best QT correction formula in a non-hospitalized population: the Fasa PERSIAN cohort study.

ABSTRACT:

Background

QT interval as an indicator of ventricular repolarization is a clinically important parameter on an electrocardiogram (ECG). QT prolongation predisposes individuals to different ventricular arrhythmias and sudden cardiac death. The current study aimed to identify the best heart rate corrected QT interval for a non-hospitalized Iranian population based on cardiovascular mortality.

Methods

Using Fasa PERSIAN cohort study data, this study enrolled 7071 subjects aged 35-70 years. Corrected QT intervals (QTc) were calculated by the QT interval measured by Cardiax® software from ECGs and 6 different correction formulas (Bazett, Fridericia, Dmitrienko, Framingham, Hodges, and Rautaharju). Mortality status was checked using an annual telephone-based follow-up and a minimum 3-year follow-up for each participant. Bland-Altman, QTc/RR regression, sensitivity analysis, and Cox regression were performed in IBM SPSS Statistics v23 to find the best QT. Also, for calculating the upper and lower limits of normal of different QT correction formulas, 3952 healthy subjects were selected.

Results

In this study, 56.4% of participants were female, and the mean age was 48.60 ± 9.35 years. Age, heart rate in females, and QT interval in males were significantly higher. The smallest slopes of QTc/RR analysis were related to Fridericia in males and Rautaharju followed by Fridericia in females. Thus, Fridericia's formula was identified as the best mathematical formula and Bazett's as the worst in males. In the sensitivity analysis, however, Bazett's formula had the highest sensitivity (23.07%) among all others in cardiac mortality. Also, in the Cox regression analysis, Bazett's formula was better than Fridericia's and was identified as the best significant cardiac mortality predictor (Hazard ratio: 4.31, 95% CI 1.73-10.74, p value = 0.002).

Conclusion

Fridericia was the best correction formula based on mathematical methods. Bazett's formula despite its poorest performance in mathematical methods, was the best one for cardiac mortality prediction. Practically, it is suggested that physicians use QTcB for a better evaluation of cardiac mortality risk. However, in population-based studies, QTcFri might be the one to be used by researchers.

SUBMITTER: Yazdanpanah MH

PROVIDER: S-EPMC8851728 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Publications

The best QT correction formula in a non-hospitalized population: the Fasa PERSIAN cohort study.

Yazdanpanah Mohammad Hosein MH Naghizadeh Mohammad Mehdi MM Sayyadipoor Sepideh S Farjam Mojtaba M

BMC cardiovascular disorders 20220216 1

<h4>Background</h4>QT interval as an indicator of ventricular repolarization is a clinically important parameter on an electrocardiogram (ECG). QT prolongation predisposes individuals to different ventricular arrhythmias and sudden cardiac death. The current study aimed to identify the best heart rate corrected QT interval for a non-hospitalized Iranian population based on cardiovascular mortality.<h4>Methods</h4>Using Fasa PERSIAN cohort study data, this study enrolled 7071 subjects aged 35-70 ...[more]

PMID: 35172723

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Dataset Information

The best QT correction formula in a non-hospitalized population: the Fasa PERSIAN cohort study.

Background

Methods

Results

Conclusion

Publications

The best QT correction formula in a non-hospitalized population: the Fasa PERSIAN cohort study.

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