Epigenome-wide association study of posttraumatic stress disorder identifies novel loci in U.S. military veterans.

ABSTRACT: Posttraumatic stress disorder (PTSD) is a chronic and disabling psychiatric disorder prevalent in military veterans. Epigenetic mechanisms have been implicated in the etiology of PTSD, with DNA methylation being the most studied to identify novel molecular biomarkers associated with this disorder. We performed one of the largest single-sample epigenome-wide association studies (EWAS) of PTSD to date. Our sample included 1135 male European-American U.S. veterans who participated in the National Health and Resilience in Veterans Study (NHRVS). DNA was collected from saliva samples and the Illumina HumanMethylation EPIC BeadChip was used for the methylation analysis. PTSD was assessed using the PTSD Checklist. An EWAS was conducted using linear regression adjusted for age, cell-type proportio

SUBMITTER: Montalvo-Ortiz JL 

PROVIDER: S-EPMC8854688 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature