Brand interchangeability of pepsinogen tests in the real-world setting after eradication of Helicobacter pylori: a community-based study.

ABSTRACT:

Background

Serum pepsinogen (PG) is recommended as a screening test for premalignant gastric lesions. However, real-world evidence demonstrating its applicability and equivalence between different test brands is limited.

Methods

Mass screening began in 2018 in a high-risk Taiwanese population after eradication of Helicobacter pylori, with the first stage of two PG tests (GastroPanel^®, Helsinki, Finland and LZ-Test^®, Tokyo, Japan) and the second stage of endoscopy. A positive test was defined as PG-I < 30 ng/mL or PG-I/II ratio < 3 for GastroPanel^® and PG-I ≤ 70 ng/mL and PG-I/II ratio ≤ 3 for LZ-Test^®. Index lesions included atrophic gastritis and intestinal metaplasia. Test performance was evaluated based on the participation rate

SUBMITTER: Chiang TH 

PROVIDER: S-EPMC8857789 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature