Spectroscopy-based multi-parametric quantification in subjects with liver iron overload at 1.5T and 3T.

ABSTRACT:

Purpose

To evaluate the precision profile (repeatability and reproducibility) of quantitative STEAM-MRS and to determine the relationships between multiple MR biomarkers of chronic liver disease in subjects with iron overload at both 1.5 Tesla (T) and 3T.

Methods

MRS data were acquired in patients with known or suspected liver iron overload. Two STEAM-MRS sequences (multi-TE and multi-TE-TR) were acquired at both 1.5T and 3T (same day), including test-retest acquisition. Each acquisition enabled estimation of R1, R2, and FWHM (each separately for water and fat); and proton density fat fraction. The test-retest repeatability and reproducibility across acquisition modes (multi-TE vs. multi-TE-TR) of the estimates were evaluated using intraclass correlation coefficients, linear

SUBMITTER: Simchick G 

PROVIDER: S-EPMC8858702 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature