Assessment of the Cow's Milk-related Symptom Score (CoMiSS) as a diagnostic tool for cow's milk protein allergy: a prospective, multicentre study in China (MOSAIC study).

ABSTRACT:

Objectives

The MOSAIC study aimed to evaluate if the Cow's Milk-related Symptom Score (CoMiSS) can be used as a stand-alone diagnostic tool for cow's milk protein allergy (CMPA).

Design

Single-blinded, prospective, multicentre diagnostic accuracy study.

Setting

10 paediatric centres in China.

Participants

300 non-breastfed infants (median age 16.1 weeks) with suspected CMPA.

Interventions

After performing the baseline CoMiSS, infants commenced a cow's milk protein elimination diet with amino acid-based formula for 14 days. CoMiSS was repeated at the end of the elimination trial. Infants then underwent an open oral food challenge (OFC) with cow's milk-based formula (CMF) in hospital. Infants who did not react during the OFC also completed a 14-day home ch

SUBMITTER: Vandenplas Y 

PROVIDER: S-EPMC8860045 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature