Nickel-Catalyzed Asymmetric Reductive Diarylation of Vinylarenes.

ABSTRACT: A nickel-catalyzed asymmetric diarylation reaction of vinylarenes enables the preparation of chiral α,α,β-triarylated ethane scaffolds, which exist in a number of biologically active molecules. The use of reducing conditions with aryl bromides as coupling partners obviates the need for stoichiometric organometallic reagents and tolerates a broad range of functional groups. The application of an N-oxyl radical as a ligand to a nickel catalyst represents a novel approach to facilitate nickel-catalyzed cross-coupling reactions.

SUBMITTER: Anthony D 

PROVIDER: S-EPMC8864584 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature